Some individuals who are highly sensitive to neuroactive peptides may prefer to begin slightly lower (100150 mcg) for the first few doses to assess tolerance before moving to the full protocol
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Andreeff M , Studeny M, Dembinski J, Cabreira-Hansen M, Zompetta C, Champlin RE, Chada S, JrFF L, Marini III FC
However, spine biomechanics complex and pain often multi-factorial (muscles, discs, nerves, joints)