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This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting

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PNAS 106(36):1542415429 Cornet D, Clement A, Clement B, Menezo Y (2019) High doses of folic acid induce a pseudo-methylenetetrahydrofolate syndrome

In CKD, uremic dysbiosis causes a decrease in microbial diversity, favoring the growth of pathogenic microbes that raise levels of compounds such as TMAO