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Toxic Dose: the therapeutic index (toxic/therapeutic dose ratio) for benzodiazepines is very high oral doses of diazepam that are 15-20 times the normal therapeutic dose have been reported without serious depression death from overdose with benzodiazepines alone is rare, however , respiratory arrest has been reported after rapid iv injection of benzodiazepines ingestion of other CNS-depressant drugs (ethanol, barbiturates, opioids) will produce additive effects (Olson 2007)

Mutations in GNE lead to the neuromuscular disorder, GNE myopathy, characterized by muscle weakness and atrophy, with protein aggregation seen in muscle biopsy samples 3

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Your goal is to inject a target dose of 250 mcg