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The transcription factor Nrf2 regulates the gene expression of a number of phase II genes such as HMOX1, GCLC, and GCLM, and NQO1, which increases cellular glutathione (GSH) synthesis

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The cloning of GPX1 has led to the identification of a specific eukaryotic Sec insertion sequence (SECIS) element as a stem-loop structure located in the 3 untranslated regions (UTR) of the glutathione peroxidase mRNAs