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The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]

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GSH was assessed in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) due to these regions suggested involvement in MA use ( 2

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Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Fruhauf J, Wallace-Povirk A, OConnor C, Hou Z, Kim S, et al

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