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Angelova PR, Abramov AY (2018) Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

Copper is also bound by regulatory proteins including metallothioneins, copper chaperones (ATOX1, COX17, CCS), and the major plasma copper-binding protein ceruloplasmin

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Increases in H 2 S levels could also potentially lead to the persulfidation (sulfhydration) and activation of enzymes such as glycerol-3-phosphate dehydrogenase 1 (GPD1) or glycerol-3-phosphate dehydrogenase 2 (GPD2) that comprise the glycerol-3-phosphate shuttle (G3PS) to increase cytoplasmic NADH redox shuttling (Petrovic et al., 2025)

Interestingly, with respect to selectivity and potential drug development, FhGST-S1 demonstrated a different inhibition profile to hGSTS11 (PGDS) when probed with a series of isoquinolyl inhibitors that were synthesised as previously described 24 (Supplementary Table 1)