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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation

For most drugs, this is a predictable obstaclepharmaceutical formulators account for it by increasing the oral dose proportionally

In non-Hodgkin lymphoma, CP is a core drug in several first-line regimens, especially B-cell lymphomas (Roschewski et al

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This issue warrants deeper consideration