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Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

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Resveratrol reduces oxidative stress and apoptosis in podocytes via sir2-related enzymes, Sirtuins1 (SIRT1)/Peroxisome proliferator-activated receptor Co-activator 1 (PGC-1) Axis