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J Cell Biol 211:11031111 Colello D, Mathew S, Ward R, Pumiglia K, LaFlamme SE (2012) Integrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling

In fact, significant weight loss (5%) is associated with a reduction in steatosis, while a weight loss of 710% has been shown to improve steatohepatitis and fibrosis