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These have been shown in models of muscle injury, tendon degeneration, and experimental colitis

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iv) non-cardiac pathologies, with severe progression, which can generate arrhythmias such as hemorrhages, various neoplasms, hematological diseases, post-surgical conditions, infectious diseases, neuropsychiatric disorders, gout, hyperuricemia, renal insufficiency, hepatic, pulmonary failure and multiorgan failure

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