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The NLRP3 inflammasome cleaves and activates caspase 1, which not only activates IL-1 but also IL-18 (171)

This review aims to outline the relevant mechanisms of ferroptosis, its implications in the bone microenvironment, and the mechanisms of action and therapeutic perspectives of ferroptosis in common bone and joint diseases, with the goal of informing future clinical research and treatment strategies targeting ferroptosis under these conditions

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