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Curcumin inhibits APAP-induced hepatocyte apoptosis by reducing the expression of pro-apoptotic genes Bax and caspase-3, inducing anti-apoptotic genes like Bcl-x1, and increasing the ratio of Bcl2/Bax (Li et al., 2013)

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Animal experiments Animal experiments were performed using hemizygous or homozygous human FcRn Tg32 mice (B6.Cg- Fcgrt tm1Dcr Tg(FCGRT)32Dcr/DcrJ, The Jackson Laboratory)