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The rate-limiting step in GSH synthesis is the availability of cysteine, which is transported into the brain from the blood via the cystine/glutamate antiporter system xc-

thus, expert opinion suggests some level of safety in human subjects may be assumed

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c , e , Exponential-phase ( c ) and stationary-phase ( e ) cultures were treated with and without 40 M KL1 and 2 g/mL Rif for 24 h, followed by a wash step and plating to enumerate surviving bacteria

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