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Interestingly, CDK4/6i treatment has been found to enhance anti-tumor immunity by suppressing regulatory T cells (Tregs) and promoting cytotoxic T-cell activity (Liang et al., 2021

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Certainly, these therapies are effective, but they most often lead to severe long-term complications such as infections, Secondary malignancy, ovarian failure, disturbances in gastrointestinal tract functionality, miscellaneous hematologic conditions that include leucopenia or anemia, organ damage, and long-term use of corticosteroids may lead to weight gain, delivery of osteoporosis, and diabetes mellitus ( Literature reviews regarding the association of probiotics with lupus indicate that they may have beneficial contributions to immune regulation and inflammation, two pivotal components in lupus pathogenesis