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The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a

At the cellular level, glutathione protects your mitochondria the tiny powerhouses inside your cells that generate energy

5 , e1015 (2014)

Bazinet A, Kadia T, Short N, Borthakur G, Wang S, Loghavi S, Patel K, DiNardo C, Daver N, Alvarado Y, Haddad F, Pierce S, Andreeff M , Jabbour E, Konopleva M, Kantarjian H, Ravandi F

Gene expression profiling reveals a signaling role of glutathione in redox regulation