69 Lipid metabolism and ferroptosis Excess ROS produced by the Fenton reaction further causes lipid peroxidation, eventually leading to cell death
Xun W, Shi L, Zhou H, et al
[115] described that phosphoglycerate dehydrogenase (PHGDH), involved in the synthesis of serine and glycine from glucose, is critical for pancreatic tumor cells proliferation and tumorigenesis, mediating cell-tight junctions formation, mTOR activation (through Akt), and protein expression and translation, after interaction with the translation initiation factors eIF4A1 and eIF4E (which seems to be independent of its enzymatic activity)
When nutrient cofactors are insufficient, oxidative demand is excessive, or sulfur metabolism is impaired, glutathione production may fail to keep pace with need
Median platelet counts at 1, 2, 3, 4, 5, 6, and 7 years on study were 85 x 109/L, 85 x 109/L, 105 x 109/L, 64 x 109/L, 75 x 109/L, 119 x 109/L, and 76 x 109/L, respectively