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Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)

doi: 10.1038/sj.jid.5700951

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Advancing Long-Acting Amylin Agonists A new review in the journal Peptides describes the past, present, and future of research on amylin agonists