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For Glutathione-based detox, we recommend using 3-5 suppositories/per week for 4 weeks

Cheng, C

Induction of endothelial cell apoptosis by heat-shock protein 60-reactive antibodies from anti-endothelial cell autoantibody-positive systemic lupus erythematosus patients

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These effects of Pycnogenol supplementation on blood pressure were investigated in a small RDP crossover study with eleven borderline hypertension patients ( supplementation with 200 mg a day for eight weeks significantly lowered blood systolic blood pressure from 140 to 133 mmHg compared to placebo, which was decreased only marginally