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UV irradiation induces DNA damage that can lead to nucleotide alterations and beneficial mutations (Lawrence et al., 1982)

If none of the above options is possible or successful, physicians often seek a clinical trial of a new agent for gout, if available, for their patient to enter

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In local synovial tissues, the hypoxic environment favors stable expression of HIF-1, enhancing the survival of pathogenic CD4 + T cell and further aggravating inflammation (141, 151)

Tamoxifen induces apoptosis in cells overexpressing Bcl2