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254 NAD + metabolism programs immunity and inflammation NAD + , along with citrate and succinate, is a novel class of metabolites with inflammatory signaling capacity, linking the NAD + metabolism to the programming of immune responses

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The main reasons for this are twofold: First, although the rectum and parts of the distal colon in humans have no direct vagus nerve innervation, VNS can activate the vagus afferent fibers, project to the central solitary nucleus (NTS), thereby enhancing the output activity of the sacral nerves and regulating the functions of the distal colon and rectum, achieving the therapeutic effect (25, 31)

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