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Despite that sleeve gastrectomy and gastric bypass, the two most commonly performed bariatric procedures today, can result in sustained long-term WL 2025% in people with obesity and T2D and in multiple cardiometabolic benefits, bariatric surgery is an intervention which is not scalable in population level and people can be hesitant to this option due to the risk of postoperative complications [12,13]

Other topical treatments include retinoids and calcineurin inhibitors, helping reduce inflammation, but retinoids can increase sun sensitivity and calcineurin inhibitors can increase the risk of certain cancers