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Characteristic findings in patients with mutations in the HMGCL gene are accumulation of leucine metabolites, 3-hydroxy-3-methylglutaric acid, 3-methylglutaconic acid, 3-methylglutaric acid, and 3-hydroxyisovaleric acid

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Recommended injection sites include the abdomen (avoiding a 2-inch radius around the navel), the front and outer thighs, and the back of the upper arms