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Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond

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Alternatively, they might synergistically enhance angiogenesis through different mechanismsBPC-157 via VEGF upregulation and TB-500 through direct effects on endothelial cells

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