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Thus, in tumor angiogenesis, CUL5 forms a multidimensional regulatory network: it enhances pro-angiogenic signals via the TRAF6/NF-B/HIF-1/VEGF axis while simultaneously suppressing the MAPK/PI3K-AKT pathway through Visfatin degradation, balancing HIF stability and MAPK phosphorylation

doi: 10.1002/ptr.6113 3 BanieckiM

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People with allergies to Asteraceae family plants Milk thistle belongs to the Asteraceae family, which includes plants such as ragweed, daisies, marigolds, and chrysanthemums