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Numerous other nutritional factors such as selenium, thiamine, riboflavin, as well as pyridoxine, cobalamin, folate, and minerals such as magnesium and zinc, aid in the methylation process, also contribute to the synthesis of glutathione

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doi: 10.1038/ni.1923 102 EisenbergVHZoltiMSorianoD

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Other research has revealed a close association between Long Covid and Hcy levels, often elevated in those with two very common enzymatic polymorphisms for MTHFR (Ponti et al., 2021)