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further proposed that ferroptosis and programmed necrosis are complementary mechanisms of cell death (104)

Roy A, Khan A, Ahmad I, Alghamdi S, Rajab BS, Babalghith AO et al (2022) Flavonoids a bioactive compound from medicinal plants and its therapeutic applications

In addition, in HFD-induced and palmitate (PA)-induced primary mouse cardiomyocyte models, increased expression of bromodomain protein 4 (BRD4) was found to inhibit PINK1/Parkin-mediated mitophagy, leading to impaired cardiac function, and the use of a BRD4 inhibitor (JQ1) was able to activate PINK1/Parkin-mediated mitophagy, thereby playing a therapeutic role in the treatment of DCM [184]

This is not a semantic distinction, since confirming the primary site will dictate the patients clinical stage and the type of therapy they will undergo

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