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Small molecule hydrophobic metabolites such as propionate, acetate, and butyrate can cross the epithelial barrier by simple diffusion along a concentration gradient from zones of elevated concentration in the intestinal lumen to places of diminished concentration in the epithelial cells (65)

Given the biphasic dose-response curve described above for cardiovascular effects, a reconstitution error that doubles the intended dose may shift the patient from a vasodilatory to a vasopressor pharmacodynamic regime

Phosphorylation of serine/threonine kinase PINK1 activates parkin and induces its translocation from cytoplasm to mitochondria, which contributes to the anti-aging effect in the heart [81]