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The observed upregulation of not only the ThDP-dependent dehydrogenases limiting and feeding the TCA cycle, but also the thiamine transporters and ThDP-producing enzyme TPK1 (Figures 4B, 5B), may compensate for decreased levels and/or increased demands of thiamine in enterocytes 69 months after gastric bypass, facilitated by the higher expression of the proteins binding thiamine or ThDP

& Gianoncelli, A

This combination provides intermediate molecules used in energy production (citric acid cycle)

PubMed Heffernan, M.A., Thorburn, A.W., Fam, B., Summers, R., Conway-Campbell, B., Waters, M.J., & Ng, F.M

Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry