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Abbreviations TME: Tumour microenvironment CAF: Cancer-associated fibroblast TAM: Tumour-associated macrophage Treg: Regulatory T ECM: Extracellular matrix scRNA-seq: Single-cell RNA sequencing EMT: Epithelial-mesenchymal transition KPC: LSL-Kras G12D/+ ;LSL-Trp53 R172H/+ ;Pdx-1-Cre SAA3: Serum Amyloid A3 LRCC15: Leucine rich repeat containing 15 FAP: Fibroblast activation protein IFN: Interferon TNF: Tumour necrosis factor -SMA: -Smooth muscle actin CSC: Cancer stem cell HGF: Hepatocyte growth factor SHH: Sonic hedgehog PDGFR: Platelet-derived growth factor receptor NF: Normal fibroblast PDPN: Podoplanin FSP-1: Fibroblast-specific protein 1 TN-C: Tenascin-C POSTN: Periostin PD-1: Programmed cell death protein 1 PD-L1: Programmed cell death ligand 1 Gal-1: Galectin-1 TKI: Tyrosine kinase inhibitor CAV1: Caveolin 1 myCAF: Myofibroblastic CAF iCAF: Inflammatory CAF apCAF: Antigen-presenting CAF HH: Hedgehog HAS2: Hyaluronan synthase 2 FGF: Fibroblast growth factor FAPI: FAP inhibitor ICI: Immune checkpoint inhibitor

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When the pods are sliced open, they release a mucilaginous liquid that is used as a thickener in stews like gumbo and other Creole and Cajun dishes

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Simone Tan Institution: Singapore Institute for Neuroregeneration Result: Peptide-based circadian entrainers (like vasoactive intestinal peptide) combined with autologous stem cells post-plasmapheresis led to substantial reduction in insomnia severity index scores and improved subjective sleep quality in clinical pilot trials