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In biochemical and cellular research systems, Vitamin B-12dependent enzymes such as methionine synthase and methylmalonyl-CoA mutase are studied for their roles in DNA synthesis, amino acid metabolism, and fatty acid processing

Thus, mitochondrial persulfide production is regarded necessary for the mitochondrial energy metabolism (Akaike et al

The putative genes identified through these studies play various roles in gut immunity, including regulating the gut mucosal barrier, autophagy, epithelial restitution, microbial defense, and adaptive immunity [24, 25]

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