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Lipids, especially polyunsaturated fatty acids (PUFAs) in membrane phospholipids, are prime targets for ROS-induced peroxidation ( ROS also damage nucleic acids, particularly guanine bases, resulting in eight-oxoguanine formation, DNA strand breaks, and telomere shortening (Zhou et al., 2025)

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on 38 observational cohort and casecontrol studies, only 29.1% of melanomas likely arose from a preexisting nevus and 70.9% arose de novo (54)

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