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In an ongoing phase 1a/1b trial of leptomeningeal metastases (malignant cells in the CSF), IT DFO will be tested through an Ommaya reservoir to determine the highest dose of DFO that can be tolerated ( Delivering drugs directly into the CSF also raises significant safety concerns

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Our data reveled excellent encapsulation stability of DDA-AuNCs in PLGA with very minimal leaching as shown in Fig