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These are complementary strategies that address weight through different biological pathways -- CagriSema through dual appetite suppression mechanisms, retatrutide through appetite suppression plus increased energy expenditure

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The most effective GLP-1 drug for weight loss currently (as of early 2026) is tirzepatide, marketed under the names Zepbound (for weight loss) and Mounjaro (for diabetes)

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Tomanin R, Zanetti A, Zaccariotto E, DAvanzo F, Bellettato CM, Scarpa M