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For an extended period, it was assumed that the active form of vitamin D (1,25(OH)2D) could be produced exclusively in the kidneys through the conversion of 25(OH)D

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Studies have shown that folate deficiency, such as exposure to the dihydrofolate reductase inhibitor methotrexate, reduces hippocampal neural stem cell proliferation and is accompanied by an increased rate of apoptosis in neonatal neurons, leading to hippocampal volume atrophy and affecting memory and cognitive function [91]

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