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In one study, after a series of four to six intra-articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity

The animal studies used both local application at the injury site and systemic administration (intraperitoneal and intragastric), with both routes showing significant effects

Most supportive claims rely on BPC-157 experiments in rats or isolated tendon cells, combined with studies of full-length thymosin beta-4

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Lifestyle and Diet: People with restricted diets, such as vegans, or those with absorption difficulties may need B complex injections more often