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Shahbazi MA, Hamidi M

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Pyruvate kinase-mediated (PKM) PEP-to-pyruvate conversion reveals dual metabolic fate: pyruvate dehydrogenase (PDH)-dependent acetyl-CoA production for TCA cycle entry versus lactate dehydrogenase (LDH)-driven lactate (LA) generation, epitomizing the Warburg phenotype

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This is where the peptide is absorbed into the bloodstream to exert its systemic effects or where it can act directly on the gut lining itself