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Further flow cytometry analysis confirmed that caloric restriction modulates the PI3K/AKT/c-Myc signaling axis and reduces granulocyte-macrophage colony-stimulating factor (GM-CSF) production in Th17 cells, thereby promoting CD4 + T cell balance (127)

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As a result, ROS have the potential of causing peroxidation of membrane lipids, aggression of tissue membranes and proteins, or damage to DNA and enzyme and generally by oxidizing low-density lipoproteins (LDL)

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