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(2020) suggested that MOTS-c could suppress the growth of colorectal cancer cells, indicating its potential as a therapeutic agent in cancer treatment.: While the research on MOTS-c is still in its early stages, the findings so far are promising

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Both subunits are constitutively expressed, however, during normoxia HIF1 is polyubiquitinated by the VHL complex mediating its degradation by the proteasome

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