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This coordination is mediated by (i) inter-organ substrate cycles, (ii) endocrine/paracrine signaling by adipose-, liver-, and muscle-derived factors (lipokines/adipokines, hepatokines, myokines), (iii) canonical pancreatic hormones, and (iv) extracellular-vesicle transfer of miRNAs and other regulatory cargo

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Finally, the authors of the previously mentioned review, Adeoye O et al , went on to state that glutathione (GSH) may have an important impact on is autoimmune issues