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Algahtani MS, Ahmad MZ, Ahmad J

Finally, we identify key open questions that currently limit clinical translation, including site-level causality, cell-type and spatial attribution in patient tissues, assay specificity and quantitative stoichiometry, and the conditions under which lactylation promotes versus restrains tumor progression

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Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity