Humoral immunity involves autoreactive B cells and plasma cells that produce high-affinity antibodies against Tg and TPO, furthering tissue injury through complement activation and antibody-dependent cell-mediated cytotoxicity (ADCC)
With this in mind, the current study explored the molecular basis underlying the differences observed between the two differentiation methods
Both oligomers and fibrils (especially the amyloid fibrils) are toxic to mitochondria (Lashuel et al., 2013)
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They can take months or years, and complete structural restoration is rare with conservative treatment alone
