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The first step involves the binding of glutamic acid and cysteine, catalyzed by GCL, to form glutamylcysteine

In fact, prostaglandin analogues, pilocarpine, and timolol have been shown to induce obstructive MGD by directly affecting Meibomian cells and influencing their morphology, survival, and proliferative capacity (Mocan et al., 2016

Accepted: July 21, 2016

Individuals with genetic predispositions to conditions like celiac disease, inflammatory bowel disease, or autoimmune disorders may be more prone to developing increased intestinal permeability