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Graphic abstract Similar content being viewed by others Introduction Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic, autoimmune disease affecting approximately 0.41.3% of the world population with unknown etiology

These responses facilitate healing and are mediated by the hypothalamicpituitaryadrenal (HPA) axis

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Cell pellets were resuspended in LDOX lysis buffer (20 mM potassium phosphate, 200 mM NaCl, pH 7.4, 0.01 mg ml 1 DNAseI) to an OD 600 of 140 and lysed by two rounds of sonication for 2 min at 50% amplitude with 2 s intervals using a Sonopuls (Bandelin) sonicator