Behroozi F, Abdkhodaie MJ, Abandansari HS et al (2018) Engineering folate-targeting diselenide-containing triblock copolymer as a redox-responsive shell-sheddable micelle for antitumor therapy in vivo
Macromolecule Content Total Structure Weight: 24.65 kDa Atom Count: 1,580 Modeled Residue Count: 188 Deposited Residue Count: 215 Unique protein chains: 1 Experimental Data Method: X-RAY DIFFRACTION Resolution: 2.00 R-Value Free: 0.228 (Depositor), 0.228 (DCC) R-Value Work: 0.175 (Depositor), 0.181 (DCC) R-Value Observed: 0.177 (Depositor) Unit Cell : Software Package: Deposition Data Released Date: 2006-09-12 Deposition Author(s): Kavanagh, K.L., Johansson, C., Rojkova, A., Umeano, C., Bunkoczi, G., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) Revision History (Full details and data files) Version 1.0: 2006-09-12 Type: Initial release Version 1.1: 2008-05-01 Changes: Version format compliance Version 1.2: 2011-07-13 Changes: Advisory, Version format compliance Version 1.3: 2017-10-18 Changes: Refinement description Version 1.4: 2018-01-31 Changes: Structure summary Version 1.5: 2023-08-30 Changes: Data collection, Database references, Derived calculations, Refinement description
The high abundance of ACE2 receptors on intestinal cells supports the persistent viral reservation, which may be a potential mechanism of PACS (Lee et al., 2020)
What makes KPV remarkable is that most of alpha-MSH's anti-inflammatory activity can be attributed to this tiny three-amino-acid fragment
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