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Examples include hypertension, heart disease, and diabetes

TAZ inhibition in hepatocytes also reduces the activation of HSCs by decreasing Indian hedgehog (IHH) signaling (99)

These amino acids are linked together in specific sequences, forming complex structures that determine the proteins function

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Metabolic diseases In addition to muscle and neurodegenerative conditions, alterations in NAD + levels and mitochondrial homeostasis are also observed in aging-associated metabolic diseases, particularly those conditions impacting highly mitochondrially-active tissues such as the kidney and liver 292,293,294