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Notably, despite their strong anti-inflammatory activity, no adverse effects were observed on the stomach mucosa

In chemically induced colitis models, AP supplementation reduced disease severity, lowered proinflammatory cytokines (TNF-, IL-1, IL-6), and decreased oxidative markers (Fado et al., 2020)

These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure

4B, 72 h) the glutathionylation of nuclear protiens in DEM treated cells reached the values of control (Fig

ROS are capable of triggering KGF receptor activation and its internalization [128]