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Risk Factors: High doses (2000mg+ daily) Long-term continuous use (6+ months) Pre-existing liver conditions Alcohol consumption use Symptoms to Watch: Unusual fatigue weakness Yellowing of skin/eyes (jaundice) Dark urine color Severe abdominal pain Loss of appetite 2

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MTT cytotoxicity studies The in vitro cytotoxicity of AP probe-net against ATC cells (THJ-16T and CAL-62) and normal thyroid cells (Nthy-ori 3 1) were evaluated by the MTT assay