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The titration ramp for cagrilintide takes 16 weeks even at the conservative cadence, which extends the side-effect runway

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The risk of gastrointestinal bleeding during acenocoumarol therapy in carriers of any of the CYP2C9 or VKORC1 variants was severely increased with exposure to weekly doses of acenocoumarol higher than 15 mg or the use of amiodarone or aspirin (62)