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Symptoms commonly seen: chronic fatigue, brain fog, exercise intolerance, hair loss, premature graying, restless leg syndrome, insomnia, dizziness, headaches

Lebrikizumab was being proposed to treat moderate-to-severe atopic dermatitis (eczema)

Most patients notice improved sleep and energy within the first 46 weeks

The studies summarized below are predominantly preclinical and should be interpreted accordingly

Methionine synthases catalyze the final reaction in the methionine biosynthesis pathway, i.e., the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, thus generating tetrahydrofolate and methionine