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Decreased intracellular levels of flavocoenzymes could cause mitochondrial dysfunction, increase oxidative stress, and interfere with nitric oxide release and thus blood vessel dilation all of these changes have been associated with preeclampsia (26)

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These data are first evidence that cereulide high producers rapidly oligomerize the precursor depsipeptides followed by subsequent cyclization, whereas less productive strains seem to accumulate NRPS-bound intermediates at the stage of tetradepsipeptides, only slowly converting them to higher oligomers